For "Single Protein" searches, we recommend that you upgrade to ProSight Lite.

ProSight Lite is a free Windows application for matching a single candidate protein sequence and its modifications against a set of mass spectrometric observations. Thanks, ProSightPTM Team

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Overview  

Welcome
Using a web portal, ProSight PTM allows identification and characterization of intact proteins (and their post- translational modifications, PTMs) using the Top-Down Approach. This site has many tools and graphical features to facilitate analysis of single (recombinant) proteins, proteins in mixtures, and proteins fragmented in parallel. Our ProSight Warehouses are annotated with all known post-translational modifications (PTMs), alternative splicing events and single nucleotide polymorphisms (SNPs) using the technique of Shotgun Annotation developed in the Kelleher Research Group. ProSightPTM is the only proteomics software that allows the user to search their tandem MS data against proteome warehouses containing the known biological complexity present in UniProt.

ProSightPTM2
ProSightPTM2 is an upgrade to ProSightPTM and is updated with databases based on the latest releases of Uniprot.

neuroPeptidomics
If your research involves the analysis of neuropeptides, please visit neuroProSight for the unique ability to search for neuropeptides against an annotated prohormone warehouse. neuroProSight is supported by the UIUC Center for Neuroproteomics on Cell-Cell Signaling funded by the National Institute on Drug Abuse Grant P30 DA 018310.

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Generate your free ProSightPTM account.

Support
Many databases for common organisms are now supported. Let us know if you have any other database requests.

Acknowledgements
Dr. John Garavelli is assisting us by incorporating the RESID database of post-translational modifications. We gratefully acknowledge these sources of generous support:

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News June 26, 2014

ProSight Lite Released at ASMS 2014: This year, at the 62nd ASMS meeting in Baltimore, MD, we released ProSight Lite, a free Windows application for matching a single candidate sequence and its modifications against a set of mass spectrometric observations.

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Mozilla/Firefox 3.0+ RECOMMENDED!
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