Using a web portal, ProSight PTM allows identification and characterization of intact proteins
(and their post- translational modifications, PTMs) using the Top-Down Approach. This site has many tools
and graphical features to facilitate analysis of single (recombinant) proteins, proteins in mixtures,
and proteins fragmented in parallel.
Our ProSight Warehouses are
annotated with all known post-translational modifications (PTMs), alternative splicing events and single nucleotide polymorphisms (SNPs) using the technique of Shotgun Annotation developed in the Kelleher Research Group. ProSightPTM is the only proteomics software that allows the user to search their tandem MS data against proteome warehouses containing
the known biological complexity present in UniProt.
ProSightPTM2 is an upgrade to ProSightPTM and is updated with databases based on the latest releases of Uniprot.
If your research involves the analysis of neuropeptides, please visit neuroProSight for the unique
ability to search for neuropeptides against an annotated prohormone warehouse. neuroProSight is supported by the UIUC Center
for Neuroproteomics on Cell-Cell Signaling funded by the National Institute on Drug Abuse Grant P30 DA 018310.
Generate your free ProSightPTM account.
Many databases for common organisms are now supported. Let us know if you have any other database requests.
Dr. John Garavelli is assisting us by
incorporating the RESID database of post-translational modifications. We gratefully
acknowledge these sources of generous support: